Ethnopharmacology

Artocarpus lakoocha belongs to Moraceae family which also known as Ma-Haad in Thai. This plant is widely distributed in South-east Asia especially Thailand. For centuries in Thai traditional medicine, the water extract of Ma-Haad has been used for anti-helmintic.

 

Scientific Information

The oxyreveratrol is a major compound found in heart wood of Ma-Haad. Oxyresveratrol exhibites potent inhibitory effect with an IC50 value of 1.2 µM on tyrosinase activity, which was is 32 times a more potent inhibition than kojic acid (IC50 40.1 µM). Oxyresveratrol has a stronger inhibition of tyrosinase on melanoma cell line than kojic acid. Oxyresveratrol offers approximately 150 times more inhibititive potency than resveratrol making the compound ideal for use as a de-pigmenting agent in the use of cosmetic skin-whitening products and medical agents for hyperpigmentation disorders, and does not exhibit any of the side-effects associated with the current market’s ‘melasma drug’ (Hydroquinone).

 

Benefits

  • Tyrosinase inhibitory activity (whitening agent)
  • Potent antioxidants and free radical scavengers activity
  • Potential neuroprotective effect and inhibits the apoptotic cell death

 

Applications

  • Cosmetics 
  • Cosmeceuticals 
  • Etc.

 

Quality Control

High performance liquid chromatography (HPLC) was used for control a quality of this herb extract with a quantitative and qualitative which oxyresveratrol is a marker.
 

Packaging

Standard Package:

  • Aluminum bottle
  • Plastic gallon container

Packaging can be provided in a variety of container types, depending on customs requirements.

 

Recommendations

  • Dosage: 2% in cosmetic products 
  • Store in cool dry place, away from light, excessive heat or freezing temperatures
  • Shelf life: 2 years