Mangosteen peel (Garcinia mangostana) has used in Thai traditional medicine for centuries, where it is valued for its powerful anti-inflammatory, wound healing and astringent properties. In traditional practices, the peel is commonly used to treat a variety of ailments, such as diarrhea, dysentery, skin infections, and fever. Its astringent effects make it particularly useful for tightening tissues, stopping bleeding, and reducing swelling, which is why it has been employed in wound healing and to treat gastrointestinal disorders. The high concentration of xanthones in the peel contributes to its strong antioxidant and anti-inflammatory effects, helping to reduce oxidative stress and combat chronic inflammation. Additionally, it has been used in tonic formulations to support digestive health, boost immunity, and improve skin condition, with its astringent nature aiding in tightening the skin and reducing excess fluid retention. With its extensive use in Thai folk medicine, Mangosteen peel continues to gain attention for its potential in modern wellness, particularly for its natural, soothing properties.